An overview of chikungunya virus infection

Cases of chikungunya virus infection in travellers returning to Spain from Haiti or Dominican Republic, April-June Endocytosis of chikungunya virus into mammalian cells: Jpn J Infect Dis.

S Afr Med J. Preparedness for threat of chikungunya in the pacific. Symptoms such as arthralgia can be lessened through administration of analgesics and anti-inflammatory compounds. The death rate is not particularly high, but excess mortality has been observed in concomitance with large CHIKV outbreaks.

Chikungunya virus infection: an overview.

Chikungunya virus induced sudden sensorineural hearing loss. Neurological complications of Chikungunya virus infection. Spread of chikungunya from the Caribbean to mainland Central and South America: However, there is little evidence linking chronic chikungunya virus disease and the development of autoimmunity.

See your healthcare provider if you develop the symptoms described above and have visited an area where chikungunya is found. Indian J Med Microbiol.

Although the fever subsides after a few days, skin involvement is often evident in the form of a morbilliform rash that may become pruritic, sometimes with hyperpigmentation, blisters, and sloughing of the epidermis. Changing patterns of chikungunya virus: Noel H, Rizzo C.

J Vector Borne Dis. Clinical features and molecular diagnosis of Chikungunya fever from South India. There is no specific therapy, and prevention is the main countermeasure.

CHIKV has recently re-emerged causing millions of infections in countries around the Indian Ocean characterized by climate conditions favourable to high vector density. Dengue and chikungunya virus infection in man in Thailand, Parallel studies of Sindbis virus, another alphavirus, show that similar mutations decrease viral dependency on cholesterol within insect cells.

Viral replication[ edit ] Transmission electron micrograph of Chikungunya virus particles The virus consists of four nonstructural proteins and three structural proteins.

During the first week of infection, chikungunya virus can be found in the blood and passed from an infected person to a mosquito through mosquito bites. A retrospective study of cases. Ultimately neutralization tests are required for a definitive diagnosis.

Proposed case definition of Chikungunya fever. Diagnosis The symptoms of chikungunya are similar to those of dengue and Zikadiseases spread by the same mosquitoes that transmit chikungunya. Uveitis during outbreak of Chikungunya fever.

As infected mosquitos often feed and rest inside homes, securing screens on windows and doors will help to keep mosquitoes out of the house. A study on chikungunya outbreak during in Kerala, south India. Chikungunya in west bengal, India. Methotrexatea drug used in the treatment of rheumatoid arthritishas been shown to have benefit in treating inflammatory polyarthritis resulting from chikungunya, though the drug mechanism for improving viral arthritis is unclear.

Atypical Chikungunya virus infections: Cytokines may also contribute to chronic chikungunya virus disease, as persistent joint pain has been associated with elevated levels of IL-6 and granulocyte-macrophage colony-stimulating factor GM-CSF. Clinical profile of chikungunya fever in patients in a tertiary care centre in Maharashtra, India.

Chikungunya Virus

Also observed was a high incidence of neonatal infections, many of them serious. In the United States, it is classified as a category C priority pathogen[35] and work requires biosafety level III precautions.

A major epidemic of chikungunya virus infection on Reunion Island, France, Because high amounts of virus are present in the blood in the beginning of acute infection, the virus can be spread from a viremic human to a mosquito, and back to a human.

Once a person has been infected, he or she is likely to be protected from future infections. The clinical signs of CHIKV infection include non-specific flu-like symptoms, and a characteristic rash accompanied by joint pain that may last for a long time after the resolution of the infection.

Large number of imported chikungunya cases in mainland France, Transmission via infected blood products and through organ donation is also theoretically possible during times of outbreak, though no cases have yet been documented.

A single mutation in chikungunya virus affects vector specificity and epidemic potential.During the first week of CHIKV infection. it remains unclear if the virus detected in the blood is released from virus-infected peripheral blood mononuclear cells.

)mint-body.comgunya overview CHIKF epidemics was obtained in La Réunion. is substantially higher than that calculated in La Réunion: approximately and India. Chikungunya Virus. Chikungunya virus is the cause of an ongoing epidemic in India and the islands of the southwest Indian Ocean (e.g., Reunion).

In India, million cases were reported in 75,76 Infection may cause uveitis with presentation several weeks after the acute febrile illness. The most common eye findings are anterior uveitis.

Chikungunya is an infection caused by the chikungunya virus (CHIKV). Symptoms include fever and joint pain. These typically occur two to twelve days after exposure. Other symptoms may include headache, muscle pain, joint swelling, and a rash. Most people are better within a week; however, occasionally the joint pain may last for months.

Chikungunya Virus Introduction. Ross, ; Staples et al., ). Genetic mutations in viral strains have allowed adaptation to more widely distributed mosquito vectors likely contributing to spread of the epidemic (Tsetsarkin et al., ). Disease in humans is characterized by fever, maculopapular rash, myalgia, and arthralgia that may persist in.


Jan 04,  · They concluded that Chikungunya virus infection elicited strong innate immunity with an abundant production of proinflammatory markers and cytokines, including high levels of alpha interferon, interleukin (IL)–4, IL10, and gamma interferon.

Chikungunya virus infection: an overview Claudia Caglioti, Eleonora Lalle, Concetta Castilletti, Fabrizio Carletti, Maria Rosaria Capobianchi, Licia Bordi Laboratory of Virology, “L.

Spallanzani” National Institute for Infectious Diseases, Rome, Italy.

An overview of chikungunya virus infection
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